From Cal Trans:
State Route 1 is now closed between Ragged Pt. (SLO 72.87) and Nepenthe (Mon 44).
I Motorists may travel north on State Route 1 from Cambria to Ragged Point (SLO PM 72.87) or south from Carmel to Nepenthe’s (PM 44)
The roadway is not passable, including to locals, between Ragged Pt (SLO 72.87)and Nepenthe (PM 44)
6:37 pm –  [Notification] [CHP]-AMBER WITH CT ON LL WITH UPDATES- INSTEAD OF MM45 IT’S MM 44 WHICH IS NEPENTHE RDWY WILL BE CLOSED THERE.
Meredith Gafill confirms the above.